Michigan Center for Regenerative Medicine

Intraosseous Treatment in MichiganTreating the bone beneath an arthritic joint

An advanced, image-guided option for knee and hip arthritis from board-certified physicians at our Rochester Hills and Grand Rapids offices.

Are You a Candidate? Call (248) 216-1008

★ 4.7 Google rating · Board-certified physicians · Rochester Hills & Grand Rapids

Medically reviewed by Robert Farhat, DO, board-certified physician

What are intraosseous injections?

Intraosseous treatment places regenerative treatment into the joint and directly into the bone beneath it, to help support the cartilage from the inside out. At the Michigan Center for Regenerative Medicine, this outpatient procedure may be an option for more severe knee and hip osteoarthritis, giving some patients another non-surgical choice before joint replacement.

Most regenerative joint treatments place cells or platelets inside the joint. Intraosseous treatment goes one step further: your physician places treatment both into the joint and into the bone just beneath the cartilage. The bone under a worn joint surface is often involved in arthritis pain, so treating it may help support the joint from the inside out.

How Intraosseous Treatment Works

Modern procedure room with C-arm imaging

Cartilage rests on a layer of bone. In advanced arthritis, that bone can become damaged and painful too. Intraosseous treatment delivers regenerative treatment, such as a concentrate of your own bone marrow cells, to that bone as well as the joint space. Precise placement matters, so it is done with x-ray guidance by physicians trained in interventional procedures.

Possible Benefits

Treats the bone under the cartilage as well as the joint, which may help more advanced knee and hip arthritis.
Another non-surgical option for some patients who were told their only choice was joint replacement.
Outpatient procedure: you go home the same day.
Shorter recovery than joint replacement surgery, with a period of limited weight bearing afterward.
Keeps future options open, since it does not use up the joint the way a replacement does.

Who May Be a Candidate?

We currently use intraosseous treatment for knee and hip pain, often for more severe osteoarthritis. It is a more involved procedure than a joint injection, and it is not right for everyone. Results vary, and some patients will still need joint replacement. Your physician will review your imaging and explain whether it fits.

Our physicians have extensive training in interventional pain management, which is critical for accurate placement. Learn more in intraosseous treatment compared to surgery and stem cell therapy and hip replacement.

Conditions

Conditions We Evaluate

Intraosseous treatment is currently used for knee and hip arthritis, often when arthritis is more advanced.

Knee Osteoarthritis

More advanced knee arthritis, including bone changes beneath the cartilage.

Hip Osteoarthritis

Hip arthritis when joint injections alone may not be enough.

Bone Marrow Lesions

Painful changes in the bone under a worn joint surface, seen on MRI.

Patient reviews

What Our Patients Say

    
 
 
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   Peter Lynde 
 11 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Excellent experience with Dr. Farhat at the Michigan Center for Regenerative Medicine. Experienced, knowledgeable and patient. I highly recommend him and the Center.
  
 
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   Heli Patel 
 62 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Great doctor .Easy to understand. Friendly staff. Very helpful
  
 
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   Kristin 
 64 days ago
 
 
 Trustindex verifies that the original source of the review is Google. The entire office staff and the doctors are great to work with, we are very appreciative of everything they have done for both myself (PRP) and my husband (stem cell therapy). The results we have experienced have been life changing and we have a renewed outlook on our overall health now!
  
 
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   paul newman 
 77 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Great place great staff.
It has been a great help for all of my injuries
  
 
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   John St Pierre 
 96 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Many thanks to Dr. Robert Farhat for the care he has given me.
The procedure  he performed has resulted in relief that has reduced the pain to the most tolerable level I’ve had in months.
It is most notable, that the staff and support team approached the entire process with speed, efficiency and above all respect.
Again, your kindness is greatly appreciated.
  
 
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   Cindy Jubeck 
 115 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Dr Nabity is one of the most caring, patient, & thorough doctors around! Highly recommended he & his team!
  
 
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   James R 
 124 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I cannot say anything good enough about Dr. Santa and the entire staff at Michian centers of Regentive Medicine! I suffered for 6 yrs with debilitating cervical instability in my c1- c2 through c7 area. Dr Santa Ana recommeneded PRP for me. Its has been life changing for me with just the 1st treatment. I have now gotten a second treatment because the 1st was so successful!
  
 
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   Christopher Micakovic 
 132 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Dr. Farhat is knowledgeable, compassionate, and genuinely cares about helping patients improve their quality of life. The office is well organized, appointments are handled professionally, and the staff is always friendly and helpful.
  
 
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   Mary Southway 
 196 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Dr. Nabity is easy to talk to and helps a lot with his procedures. I had PRP on my Right shoulder for tear in my rotator cuff. My shoulder is feeling 99% better. Only when I over do it do I have some discomfort.Grateful that I didn’t have surgery & saw Dr Nabity.
  
 
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   John Pearl 
 208 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I have had several operations this was by far the very best everyone was friendly new there job I have told everyone I would do it again it was such a great experience
  
 
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   J Dub 
 271 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Great clinic for PRP scalp treatments.
  
 
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   Brian Olejniczak 
 274 days ago
 
 
 Trustindex verifies that the original source of the review is Google. DR. SANTA ANA helped me with my spinal back pain.
  
 
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   Branden Bauer 
 279 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Caring, knowedgable and fixed my neck pain.
  
 
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   Swamy Akasapu 
 313 days ago
 
 
 Trustindex verifies that the original source of the review is Google. My knee surgery was done at this facility. The staff are excellent in attention to details. Strongly recommend.
  
 
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   tammy lester 
 361 days ago
 
 
 Trustindex verifies that the original source of the review is Google. 
  
 
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   Anthony Richards 
 385 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Efficient, friendly environment.  Helpful staff.
Excellent doctor with great insight.
  
 
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   Steve Mitchell 
 404 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Procedure on lower back is working.  Feeling better every day. Dr. Farhat was very kind, patient, and helpful.   Great bedside manner.
  
 
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   Carolyn Burrus 
 414 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I am very happy with the knee injections.Both knees without pain .
  
 
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   Lise Shirtz 
 446 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Dr. Robert Farhat is extremely professional, educational & most of all cares about his patients. I went there for a tear in my shoulder, had platelet replacement therapy/surgery. (I had struggled for 6 months before this, going to PT, etc. no luck,
and I did not want regular surgery.)
I am back to lifting weights as prior to my injury, hiking etc.  I am a True believer in this type of medical procedure!
  
 
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   T Baugh 
 447 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Dr Farhat is the best when it comes to pain management. He is a doctor that actually listens and he truly cares about his patients. The staff goes above and beyond to help. Excellent medical team. I highly recommend!
  
 
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   Arthur Williams 
 447 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Very friendly. On time and very professional. I have had great results. Dr Nabity is thorough and has a great bedside manner. I highly recommend.
  
 
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   Judith Schwagle 
 461 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Dr. Nabity is awesome!  He spent over an hour with my husband and me going over my MRI’s for hip issues and all other information. He explained everything about PRP and answered all my questions. While  we were there, he even checked out my husband’s hip problem too and gave him suggestions as well. I am very pleased with the plan of action we chose together. Looking forward to healing!!
  
 
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   M Fuller 
 477 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I’ve been coming here to bring my wife since the other builder an to my surprise it was a guy there Name Joe!  His badge said lead receptionist. His hospitality customer service was simply outstanding. He offer me, coffee water, and even asked me would I be interested in some services which was great because you all have services geared towards men and it’s just a little bit more comfortable talking to a guy. So Thank you Sir I hope the Doctors give u a hi five for a awesome Job
  
 
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   Mary BeesVideo 
 519 days ago
 
 
 Trustindex verifies that the original source of the review is Google. These doctors really listen to you, and they give you different opinions to help with pain management. My sister told me about them, one of the best decisions I’ve made in a long time.
  
 
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   Anthony Karpowitsch 
 543 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Dr farhat is an amazing doctor that actually cares about his patients. The surgery team like the nurse and anesthesia Dr were phenomenal. I highly recommend this doctors office. Everyone from the front office staff to the medical assistants are so friendly and knowledgeable. 5/5
  
 
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   James Grech 
 567 days ago
 
 
 Trustindex verifies that the original source of the review is Google. This is only a review for the first consultation.  I met with Dr. Santa Anna and I was very impressed with his ability to explain my options after looking at my previous MRI's and also doing ultra sound on my shoulder.  I did not feel any pressure and he gave me multiple options with his opinion on what would be the best option.  I have not gotten any procedures yet and will update after I do.  This is for those that might be nervous about going here for their first consultation.
  
 
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   Jason Buynak 
 571 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I have been seeing Dr. Farhat for almost 5 or six years now.  Was in an auto accident that has given me problems which led to five surgeries over the last six years. He is one of the only people that I believe that has helped my pain from my back and from my neck. He joined a wonderful group of doctors that I had seen before and I would have nothing but good things to say about every single one of them and highly recommend any of these physicians to anybody that needs care to get out of the ailment’s they have.  You should have every bit of confidence in the care that they provide. They have put the care back in healthcare that has been so deeply diminishing with our insurance companies. See these guys first before you do any major surgery!
  
 
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   Isaac Schaberg 
 672 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Thank you doctor Farhat! Before visiting the Michigan Center For Regenerative Medicine. I had been dealing with a herniated disc for over a year. At times it was debilitating, and made doing most things unbearable. I am 4 weeks post stem cell and PRP injections and the difference I feel is unbelievable. My back pain is gone and I feel amazing! I am so thankful to have gone to the Michigan Center For Regenerative Medicine. It is 100% worth it.
  
 
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   Derek Voigt 
 674 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I saw Dr Nabity for an ankle issue I had been dealing with for a year.  Dr Nabity was very personable and really listened to me about my issue.  He then offered a solution and explained why this he suggested this particular solution.  3 months after the procedure I’m having great improvements and am well on the way to full recovery.
  
 
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   Charlotte Douglas 
 756 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I’m grateful for the care and attention I received by Dr Farhat and his staff pertaining to an auto accident injury I sustained. He was extremely helpful in my recovery! I did not feel pressured into anything and everything was explained to me in detail so I knew what to expect. I received a PRP procedure on my neck and EMP.  He also helped coordinate with other doctors to make sure I got the help I needed. He went above and beyond and for that I am truly grateful and highly reccomend this practice to others. 5 stars! ⭐️ ⭐️ ⭐️ ⭐️ ⭐️
  
 
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   samie ledyard 
 764 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I am very happy with my stem cell therapy.   I can now walk without a limp most days and it's only been 12 weeks.  I would and do recommend this office and procedure to everyone.
  
 
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   John Furlano 
 808 days ago
 
 
 Trustindex verifies that the original source of the review is Google. They did an excellent review of my symptoms to determine the best treatment plan for me, which resulted in a great outcome! No high pressure sales, just first class medical consultation to assist with making my own choices!
  
 
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   Jody DeRosier 
 840 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Dr. Farhat and his team are fantastic!  After he helped me through resolving some lower back pain last year, I returned this spring for PRP in both knees.  This procedure greatly improved my everyday activities:  getting up from a chair, getting in and out of a car, and so much more!  An added bonus is that I had been taking pain reliever once or twice a week for achey knees, but I haven't needed it even once since.  A total win!
  
 
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   Carol Frontczak 
 854 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I had been suffering with a lumbar herniated disc for two years and did not want pain injections when I saw Dr. Nabity. After reviewing my MRI he told me I would be a candidate for stem cell injections. He explained everything and I had the procedure. It has been 3 months and my pain has reduced and my mobility has increased. I would highly recommend Dr. Nabity and MCRM.
  
 
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   MaryAnne Rizza 
 859 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Lower back pain gone,  knee pain significantly reduced.
  
 
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   Christy Pass-Livingston 
 860 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I highly recommend Dr Santos and Dr Farhat. We've had two issues in our family, my husband had debilitating arthritis and Dr Santos did a stem cell procedure a few years ago, it saved my husband's life.  His pain was so severe and crippling, he was walking with a cane, it would take him 10 minutes to be able to get out of bed, even riding in a car would cause him excruciating pain.  Within months of the procedure, he was able to start walking without a cane and his back continued to improve.  He even went sky diving about a year later. We took my son here to see Dr Farhat about peripheral neuropathy.  Dr Farhat had a great bedside manner.  He took the time to talk to my son and exam him. Unfortunately a stem cell procedure is not an option to help with neuropathy, but he prescribed mediation that has taken away the severe pain he was experiencing.  Other doctors we saw didn't take the time and just wrote my son off.  Just after a couple of weeks on the medication, my son's pain is nearly gone.  I can't thank the doctors enough for how much they have helped our family.
  
 
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   Teresa Ransom 
 952 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I highly recommend this clinic! I'm Canadian, and went there for prolotherapy injections for tailbone pain and knee hypermobility. Doctor Santa Ana was thorough, heard me out and even adjusted his treatment plan to target a particular ligament, as I requested. I have found the treatment very helpful and my pain is much much improved. Dr. Santa Ana went above and beyond . Thank you so much!
  
 
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   Trisha Ward 
 960 days ago
 
 
 Trustindex verifies that the original source of the review is Google. It has been 3 months since I had my bone marrow/PRF & PRP treatments.  I had my left knee, both hips and L-3,4,5 transplant-injections.   Before treatment my pain level was unbearable. I couldn’t get through a day or night without pain. I couldn’t sleep on my side (hips), my knee woke me up many times each night.  I tried Physical Therapy twice, acupuncture and was told to try cortisol shots.  I did not want to just have a temporary solution, if that would have helped at all. I do not have any pain in my knee now.  My hips and back pain is a One to Two on the pain scale now because I now can exercise twice a day for 20-30 minutes.  The procedure was not painful at all.  I am thankful for the Doctors and Nurses at the Michigan Center for Regenerative Medicine.   My body is only three months into this journey of healing, I will continue to heal and improve over the next three months.   Many thanks Dr. SantaAna.
  
 
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   Sherry Wood 
 981 days ago
 
 
 Trustindex verifies that the original source of the review is Google. After years of enduring excruciating pain and sleepless nights, I found relief at the Michigan Center For Regenerative Medicine. Chronic back and shoulder discomfort had taken a toll on my well-being, leaving me fatigued and irritable. My family even nicknamed me "Shrek" due to my constant agony. However, thanks to the expert care I received at the center, I've experienced a remarkable transformation. Following treatment for my back and shoulder, I am now able to lift my arm over my head—a simple task that had eluded me for years. Today, I am no longer plagued by pain and misery, and I finally find myself living a life filled with happiness and comfort. (from Tom Lints)
  
 
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   Kris Pline 
 1002 days ago
 
 
 Trustindex verifies that the original source of the review is Google. I was having serious SI joint flares for a few months and was having a hard time working because of the pain and inability to walk very well.  I then started physical therapy but was not able to do my exercises very well because of the pain.  I heard about PRP and contacted the Michigan Center for Regenerative Medicine.  I was able to get PRP done the next week and it was a life saver!  I truly thought I was never going to be the same again. All the staff and Doctor Santa Ana were super kind and helpful during the procedure.  I felt better right away and have not had a flare since the procedure.  I am so thankful and recommend this to anyone with severe pain!
  
 
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   Cheri Furlano 
 1008 days ago
 
 
 Trustindex verifies that the original source of the review is Google. Dr Nabity takes the time needed to explain procedures and answer questions and concerns. The procedure went well and my bodies response has been a success. The pain I had is effectively gone. This has been a really great experience.
  
 
 
  
 
 
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In Their Words

We were amazed at how thorough the explanation of the recommended procedure was. I knew just what would happen and what I was agreeing to.

Steve G. Regenerative medicine patient

This doctor is very professional, using layman’s terms and taking his time with my parents to fully explain everything, and in answering all our questions!

Rosanna Windsor, Ontario · Family of a stem cell patient

Dr Nabity answered every question/concerns I had prior to the procedure in detail. If you leave a message for him he always calls you back himself.

Connie H. New Baltimore, MI · Stem cell patient

Excerpts from our patient testimonials.

Individual results vary. Reviews reflect each patient’s own experience.

Doctor chatting with an older man at his desk

Your visit

Your Path to Treatment

Most visits follow four simple steps. Our team guides you through each one and answers questions along the way.

1. Consultation

Meet your physician, talk through your symptoms, and review your history and goals.

2. Diagnosis & Imaging

Ultrasound or other imaging helps identify the source of your pain.

3. Treatment

If intraosseous treatment fits, your physician places it with x-ray guidance in an outpatient visit.

4. Follow-Up

Check-ins track your progress and adjust your plan as needed.

Start With a Consultation

Call (248) 216-1008

Insurance & cost

Insurance, Self-Pay, and Clear Pricing

We accept many major insurance plans for consultations, testing, and many spine and joint procedures. Regenerative treatments such as PRP and stem cell therapy are usually self-pay, so you get a clear estimate before you decide.

Usually billed to insurance

Consultations and office visits
EMG and nerve testing
Epidural, facet, and SI joint injections
Nerve blocks, radiofrequency ablation, and nerve stimulators

Usually self-pay

PRP and stem cell therapy (BMAC)
Prolotherapy
PRP hair restoration
Stem cell banking

Self-pay options include prompt-pay discounts, payment plans, and HSA or FSA funds for eligible expenses.

See accepted insurance PRP cost guide

Plans we accept

PPO Trust

UMR coming soon. Blue Care Network plans require a referral. Coverage varies by plan and service, so call Rochester Hills (248) 216-1008 or Grand Rapids (616) 288-1109 and we will check your benefits.

Why patients choose MCRM

Board-certified physicians Every procedure is performed by a board-certified physician, not a technician.
Image-guided precision Ultrasound or fluoroscopic (x-ray) guidance places treatment exactly where it is needed.
Your own cells, prepared on site Platelets and bone marrow cells are processed in our in-house lab during your visit.
Results we track We have reported patient outcomes to the DataBiologics registry since 2019.
Clear, upfront pricing Itemized estimates before treatment, prompt-pay discounts, and payment plans.
Physicians who teach physicians Our doctors teach orthobiologic courses and helped write national back pain guidelines.

Our physicians

Meet Your Care Team

Thomas Nabity, MD
Board-certified physician

John Santa Ana, DO
Board-certified physician

Robert Farhat, DO
Board-certified physician

Kevin M. Nemeth, MD
Board-certified physician

John Steele, MD
Board-certified physician

Christopher Hannasch, DO
Board-certified physician

Credentials & memberships

Training You Can Look Up

Board certification shows a physician completed specialty training and passed independent exams. Our physicians go further, with added certifications and memberships in orthobiologics, musculoskeletal ultrasound and electrodiagnostic medicine. Each program is run by an independent organization, so you can see exactly what it requires.

PM&R Board Certification

Board certification in physical medicine and rehabilitation, the specialty focused on restoring function.

About ABPMR

Pain Medicine Board Certification

Board certification in pain medicine, covering evaluation and treatment of complex pain conditions.

About ABPM

IOF Certification Courses

Advanced knee, hip and spine certification courses in image-guided orthobiologic procedures.

About IOF courses

IOF Instructors & Training Hub

Our physicians teach other doctors as IOF instructors, and our Rochester Hills clinic hosts training.

About our training hub

Musculoskeletal Ultrasound

Certified in diagnostic musculoskeletal ultrasound, the imaging used to guide our treatments.

About RMSK

Electrodiagnostic Medicine

Board certification in electrodiagnostic medicine, the specialty behind EMG and nerve testing.

About ABEM

American Academy of PM&R

The national society for physiatrists, physicians focused on restoring movement.

About AAPM&R

Interventional Pain (ASIPP)

A society that sets education and practice standards for interventional pain medicine.

About ASIPP

Orthopaedic Medicine (AAOM)

A physician group focused on non-surgical musculoskeletal care, including prolotherapy.

About AAOM

DataBiologics Registry

We report patient outcomes to a national orthobiologics registry to track results over time.

How we track outcomes

Patient stories

Hear From Our Patients

Patients describe their own experiences with care at the Michigan Center for Regenerative Medicine. Individual results vary.

Patient Testimonial

FAQ

Intraosseous Treatment Questions

Answers to common questions about intraosseous treatment. Your physician can address your specific situation during a consultation.

What is intraosseous treatment?

Regenerative treatment placed into the joint and into the bone just beneath the cartilage.

Which joints are treated?

We currently use intraosseous treatment for the knee and hip.

Who is a candidate?

Often patients with more severe knee or hip osteoarthritis. Your physician reviews your imaging to decide.

Is it an outpatient procedure?

Yes. You go home the same day.

How is it guided?

Your physician uses x-ray guidance for precise placement.

What is recovery like?

Recovery is shorter than joint replacement surgery, with a period of limited weight bearing. Your physician will give you a plan.

Can it replace joint replacement surgery?

For some patients it may delay or avoid surgery. Others will still need a joint replacement.

What is placed in the bone?

Usually a concentrate of your own bone marrow cells. Your physician will explain the plan for you.

Is it covered by insurance?

Regenerative procedures are usually self-pay. Our team will give you cost information first.

How do I schedule a consultation?

Call (248) 216-1008 for Rochester Hills or (616) 288-1109 for Grand Rapids, or use the short form on this page.

Smiling senior doctor talking with a patient

Still Have Questions?

Talk with our team about your knee or hip arthritis.

Grand Rapids: (616) 288-1109
Rochester Hills: (248) 216-1008

Are You a Candidate?

Keep learning

Find Out if Intraosseous Treatment Is Right for You

Answer a few short questions and our team will contact you to schedule a consultation.

Share your symptoms and goals in the short form.

Our team contacts you to schedule a consultation.

Meet a board-certified physician in Grand Rapids or Rochester Hills.

★ 4.7 Google ratingBoard-certified physiciansTwo Michigan clinics

Prefer to talk?Rochester Hills (248) 216-1008Grand Rapids (616) 288-1109

Free webinar replay

Watch: Intraosseous Treatment for Knee and Joint Pain

Watch the replay of our physicians’ webinar on intraosseous treatment for knee and joint pain.

Our physicians host free webinars with live Q&A. Watch any past webinar on demand, or call us to ask about the next date.

Watch Past Webinars Ask about upcoming dates

Our locations

Visit Our Michigan Clinics

Rochester Hills Clinic

355 Barclay Cir, Suite A
Rochester Hills, MI 48307

(248) 216-1008

Monday–Friday, 9:00 am–4:30 pm

Get directions View clinic details

Grand Rapids Clinic

1000 E. Paris Ave SE, Suite 221
Grand Rapids, MI 49546

(616) 288-1109